178. The Surprising Truth About Librela and Solensia Nobody Tells You

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Welcome back, pet parents.
I hope you and your family and

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your fur babies had a wonderful
holiday.

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I know we're in this weird place
where like time doesn't exist

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right after the holidays and
like going into the new year.

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And I just want to say thank you
so much for being here with us.

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Being a dedicated pet parent.
I have a very, very important

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episode today, and I have been
planning this for, gosh, a

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couple of months now just trying
to gather information and get it

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to you.
And I'm hopeful to have a

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particular veterinarian back on
the podcast to talk to you about

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it some more because we can't
get the word out quick enough or

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far enough.
And So what we're going to be

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talking about today is a
prescription medication for

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dogs, it's called Librella.
For cats, it's called Silencia,

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but it's basically the same
thing.

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So what I'm going to do is just
give you a rundown of everything

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I have learned about this and I
will and I'll give you some

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recommendations of where to go
to learn more about this.

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Because everything that I have
learned about it and has been

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from Doctor Josie Bug, who has
been on the podcast in the past.

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And hopefully I'll be able to
have her back on to talk a

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little bit more in detail about
specifically about what to do if

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your animal has had this
injection once or multiple times

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or there's so much unknown
around it.

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So really quickly, let me let me
do my little spiel.

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We'll jump into everything.
If you're new here, my name is

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Jessica.
I am a canine nutritionist, a

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feline nutritionist, a holistic
pet health coach, and a positive

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reinforcement dog trainer.
And of course, I'm also the host

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of this podcast that you're
listening to right now, the Pet

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Parenting Reset.
I'm so happy you're here.

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I'm so happy you have decided to
be the best pet parent you can

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be and continue to learn and
increase our pets health span.

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That's the goal here really
quickly.

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If you do want, I am still doing
one-on-one consultations.

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My packages are changing in the
new year.

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I'll have my existing package up
for a little while just to give

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people a little bit of time to
get used to the new packages.

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But you can find all of that at
jessicalfisher.com.

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Also LinkedIn the show notes.
So let's get into Librella and

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Silencia.
So right off the bat, I'll, I'll

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give this to you again at the
end, but pet pet.

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So Pet advocare.com is a website
you can go to learn more if you

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have more questions and I'm sure
you will because this is a very

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complex topic.
And again, all of this

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information I have been learning
over the past few months from

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Doctor Josie Bug.
So Librella is what it's called

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for dogs.
Silencia is what it is called

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for cats.
And it's it's considered by the

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FDA a biologic and a biologic is
considered the same thing as a

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vaccine.
This is a monoclonal antibody.

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It's the same class as
Cytopoint.

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So one of the biggest problems
here is that the pharmaceutical

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reps are promising that there
are absolutely no side effects.

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So veterinarians who don't have
the time, energy, whatever to do

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their own research, who trust
their pharmaceutical reps are

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believing that there are
absolutely no side effects and

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don't understand when patients
come back in with all of these,

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like, adverse reactions, they're
not connecting the dots because,

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Oh my gosh, the pharmaceutical
company says there's absolutely

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no side effects.
What it is, is a once a month

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injection for arthritis and it's
intended to be received

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indefinitely, which to me is the
biggest red flag, right?

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We should never ever, ever
unless outside of, you know, a

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type 1 diabetic who literally
cannot live without insulin.

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Like, and maybe a couple of
other cases that I just can't

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think of off the top of my head.
Like we should not be ever

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considering a pharmaceutical for
life.

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Like, that does not make sense.
It makes sense to their

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pocketbooks, but it doesn't make
sense to our health or to our

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pets health.
And then fortunately and one of

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the one of the both cool things,
but also really scary things

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that I learned is that different
countries are getting different

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package inserts.
Now, you probably, if you have

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been offered this for your pet,
maybe the first time they get

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it, you're like, Oh my gosh, is
a miracle, right?

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But hear me out because there's
so, so much going on.

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And at the end of this, the
while I was preparing for this,

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the FDA actually issued a
warning letter to veterinarians

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on this drug.
So there is hope that our

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veterinarians are going to learn
that this is not the miracle

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that they, they were sold
basically by the pharmaceutical

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companies.
So the reality is there are so

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many adverse events being
reported, but what is it first?

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So it is a genetically
engineered protein creating

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created using recombinant DNA
specific to different things in

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the body.
So right now what it is doing is

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attacking or it's binding,
excuse me, to nerve growth

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factor and creating biologically
inactive nerve growth factor.

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And by doing this, it is
reducing or eliminating the pain

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of arthritis.
Really interestingly, and I just

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want to throw this in, I was
listening to Doctor Karen Becker

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and Rodney Habib, who when the
FDA came out with their warning

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letter did like a quick, I don't
know like 12 minute video, which

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I wish I could publish for you
on here, but I, I don't know

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that I have the rights to do
that.

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So what I can do is put the link
in the description or in the

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show notes.
So if you want to go watch that

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you can on I'll put the link to
Instagram.

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Thank you.
But what I heard, one of the

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things I heard Doctor Karen
Becker say on this live that was

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so interesting to me, is that
she has had reports of

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veterinarians who, because they
did not do their research and

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they don't understand what this
actually is and how this

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actually works, have been using
it in place of NSAIDs.

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So for all kinds of pain, not
just arthritis.

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And that is one of the most
scary things I've heard because

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it is absolutely not a
replacement for NSAIDs in any

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situation.
It was only designed by the way

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this medication was originally
brought for humans and failed.

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So the FDA said, no, we're not,
we're not doing this, you can't

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do this.
And so they just relabeled it,

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rebranded it and are giving it
to pets now.

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So there are so many side
effects listed in the package

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insert, not necessarily in the
one in the United States.

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So I think that one, they have
continually been changing up.

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But if you go to like the ones
from Europe from According to

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Doctor Josie Bug, there are so
many side effects listed.

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Increased BUN, lethargy,
vomiting, anorexia, lameness,

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cough, bacterial skin
infections, injection site

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reaction, UTI's, dermatitis,
dermal masses, redness, cysts,

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pain on injection, urinary
incontinence, increased drinking

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and thirst, ataxia, lack of
coordination, seizures,

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anaphylaxis, diarrhea and death.
So in the body, this is a

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foreign protein.
So in the body, this is a

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foreign protein and it is a
large antibody that creates an

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antigen, creates a large
antibody antigen process say

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that five times fast.
It is making the nerve growth

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factor biologically inactive in
the body.

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And what?
But one of the scarier things

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again in all of these side
effects that are being seen is

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that the theory here is that the
only thing nerve growth factor

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is doing is pain and weakness.
That's all that it's

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controlling.
And so when it inactivates nerve

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growth factor, it's removing the
pain and weakness of arthritis.

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The reality is nerve growth
factor does so much more.

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It help, it regenerates
everything in the joints and so

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many things we actually don't
even know yet that nerve growth

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factor does.
We're constantly learning new

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things that it does.
And so it's inactivating

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everything else.
Especially hate to hear younger

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animals being given this because
you're inactivating nerve

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growth, you're you're
inactivating all of it in the

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body.
And we don't have long term

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studies on it to know if it's
reversible at this point.

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So many animals, so many dogs
and I'm sure cats, but I, I

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think it is more prevalent in
dogs right now.

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But I think by that, I mean I
think more dogs are receiving

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Librella and not as many cats
are receiving Silencia, though I

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don't know, that could be
changing.

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It could just be that people are
more aware and paying attention

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to what's going on with their
dogs.

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I think that often is a case
with our pets.

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And I've talked about that
before on the podcast as well.

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So again, according to Doctor
Josie, bug nerve growth factor

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is a peptide.
We actually know very little

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about it, but we do know that it
is involved in the maintenance

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repair and neuroplasticity and
joints and heart tissue and it

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does seem to cross the blood
brain barrier.

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And so by the way, just a
reminder Librella Salincia are

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in activating this.
So what happens when we

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introduce these really large
foreign proteins into the body

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while we because that's what a
monoclonal antibody does, it

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creates immune reactions.
And so there are four different

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types, type 1, type 2, type 3
and type 4 of immune mediated

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reactions and this one is
causing problems all over the

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body.
She also is very, very clear

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that comorbidities are not
studied.

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So any of the packaging inserts,
even the one in the United

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States, very clearly says that
it is only for animals that do

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not have any other like disease
processes going on.

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That's kind of scary because I
would imagine many of these

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animals actually do.
That's the world we live in,

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right?
Actually, and I was wrong about

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Europe having the most extensive
package insert.

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I wrote this down because it was
important to me.

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The most thorough package insert
is actually from Canada.

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The next one is in the UK.
And then according to Doctor

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Josie Bug in the United States,
it pretty much mostly says, we

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don't know, like they are
basically passing off, like

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they'd have no liability.
It hasn't been studied.

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We don't know kind of thing in
the packaging inserts.

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So what has happened over the
past almost year is that a group

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of people, including Doctor
Josie Buke, who I was just

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talking about and where I've
learned all of this information

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from, have been putting
together, gathering data from

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people who whose pets have been
on this medication, who have

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been given this injection.
And so the statisticians have

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gone through, come through all
of the data.

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These are the most reported side
effects.

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Increased thirst, increased
urination, lack of efficacy,

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meaning that it doesn't work.
Lethargy, incontinence, death by

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euthanasia, vomiting, ataxia,
seizures, anorexia, dogs dying

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within hours of receiving the
injection within hours or days,

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partial or complete paralysis,
progressing to incontinence,

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seizures and death, sudden
blindness, dementia, lupus and

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other autoimmune conditions.
So one of the things when I was

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listening to Doctor Buve on
Doctor Judy Morgan's, Judy

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Morgan's podcast, she was saying
our best hope right now is if

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your pet has received this
injection, best outcome, the

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best we can do right now is to
keep your pet alive for a month

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for it to wear off in the hopes
of going back to normal.

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If your pet has had more than
one injection, there's a half

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life calculator on the website,
which again is pet advocare.com.

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But it's not necessarily the
same for every pet.

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It may work once or twice and
then it may not work anymore.

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And there are so many serious,
very serious side effects that

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it for her.
And I think for me too, it's

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just not worth it.
I mean, of course for you, you

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have to make that decision for
your pet.

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But what I do want to do is say
that again, the FDA did issue a

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letter to veterinarians.
It was on, I want to say

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December 17th or 18th.
Actually let me pull it up here,

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I'm sorry, December 16th and it
says the this is on fda.gov

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website.
FDA notifies veterinarians about

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an adverse events reported for
Librella and here is the letter.

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Dear Veterinarian the US Food
and Drug Administration's Center

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for Veterinary Medicine has
completed an evaluation of

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adverse events reported in dogs
of various ages treated with

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Librella.
The adverse events identified

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and analyzed include ataxia,
seizures, other neurologic signs

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including but not limited to
paresis, recumbency, urinary

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incontinence, polyuria, and
polydipsia.

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In some cases, death, including
euthanasia, was reported as an

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outcome of these adverse events.
The FDA is making available

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reports containing summaries of
clinical signs reported for

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00:14:03,960 --> 00:14:07,800
Librella in the CVMFOIA FOIA
electronic reading Room.

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Drug Information.
The FDA approved Librella, a

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monoclonal antibody drug used
for the control of pain

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associated with osteoarthritis
and dogs, on May 5th, 2023, and

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it was introduced to the
marketplace later that year.

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Prior to approval, the FDA
reviewed available studies and

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other data on Librella and
determine Librella to be safe

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00:14:27,480 --> 00:14:31,520
and effective for its intended
use for control of pain

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associated with osteoarthritis
in dogs.

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Librella is dosed by weight and
labeled for subcutaneous

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injection once a month.
What should a veterinarian do if

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a patient treated with Librella
has an adverse event?

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If a dog under your care
experiences an adverse event

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while receiving Librella, the
FDA encourage you, encourages

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you to report it to Zoetis, the
drug sponsor, and gives the

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phone number.
Drug sponsors are required to

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submit reports of adverse drug
events to FDA.

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If you would prefer to report
directly to

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00:15:03,920 --> 00:15:08,240
fdapleaseseefda.gov/report
Animal AE.

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When reporting adverse events to
the FDA and or Zoetis, please

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include, if available, a full
medical history, how many times

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the dog has received Labella,
and the lot number on the vial

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used.
Where can veterinarians get more

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information about the adverse
events that have been reported

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to the FDA?
The FDA is posting reports

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00:15:25,960 --> 00:15:28,720
containing adverse drug event
information for Librella on a

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00:15:28,720 --> 00:15:32,440
rolling basis in the FOIA
Reading room for CBM.

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If the agency has additional
information to share, it will be

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made available additional
information.

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00:15:37,880 --> 00:15:40,960
The FDA monitors the safety
profile of all animal drugs

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00:15:40,960 --> 00:15:43,720
after they reach the market, as
widespread use of a drug in a

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large number of patients may
uncover adverse events not

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observed prior to approval.
Meaning your pet is the

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experiment, and I'm not saying
that they're saying that

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00:15:56,360 --> 00:15:59,160
pharmaceutical companies.
Drug sponsors are required to

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report all cases of adverse
events they receive from the

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00:16:01,760 --> 00:16:04,600
public, including pet owners and
veterinarians, to the FDA.

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The agency evaluates adverse
events and other safety

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information when it becomes
available and it goes on just a

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little bit, not much.
Now, of course, Zoatis has their

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own response and it says we
continue to have the utmost

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confidence in the safety and
efficacy of Librella.

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Go figure.
So basically, again, Doctor

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Josie Bug is the one that I have
been getting so much of this

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information from and following
on this issue believe Silencia

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is the exact same thing for
cats.

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I am hoping the FDA also issues
a warning for Silencia.

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You can go to petadvocare.com,
PET advocare.com if you would

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like to learn more.
And you know, this is just this

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is an ongoing thing.
It's really of course sad to me

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that our pets are the experiment
most often because this in my

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opinion, especially knowing that
it was disapproved for humans,

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00:17:07,359 --> 00:17:10,079
it should never have been
approved for our pets.

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The adverse events being listed
in packaging in other countries

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and not in the United States is
terrifying.

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I think we're seeing so many
people are waking up to the fact

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that other countries definitely
have their citizens best

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interest at heart, more so maybe
not completely more so than

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agencies in the United States
do.

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And we have to be constantly
looking and researching and

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doing our own research and
figuring things out and doing

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what we feel is best for our
pets and for ourselves.

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So with that, I just, you know,
again, I, I hope to get Doctor

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Josie Beau back on to talk about
this some more.

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As she said, the best we can
hope for right now.

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If your pet has received an
injection of Librella or

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Silencia, keep them alive for
the month so that it has time to

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wear off.
And we cross all of our fingers

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00:18:08,040 --> 00:18:12,680
and toes and hope that the pet
does get back to normal.

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Unfortunately, that's not what
she and other people in the

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00:18:17,960 --> 00:18:22,440
field are seeing with this
particular pharmaceutical.

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So yeah, there's that.
There's so many other things

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that we can do in relation to
arthritis and osteoarthritis,

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namely some of the things that I
would start with.

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Of course, when I work with a
client one-on-one, I am always

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looking for, you know, I'm
looking at that individual's

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symptoms and needs.
And so it can vary, but I'm

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always looking to create an
anti-inflammatory diet.

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00:18:51,520 --> 00:18:57,280
I am using very strategic
supplementation, high doses of

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Omega threes again for
anti-inflammatory properties,

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potentially like to mark
curcumin.

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Full spectrum hemp extracts are
amazing for helping manage pain,

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medicinal mushrooms for both for
inflammation and for overall

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immune support.
Because what we really need to

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do is support the body and not
attack the symptoms.

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And I, I know I say this all the
time and maybe I sound like a

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broken record, but that is
always the case.

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Supporting the body, supporting
the immune system, providing an

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00:19:29,680 --> 00:19:33,680
anti-inflammatory body, creating
an environment that is

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00:19:33,680 --> 00:19:37,120
anti-inflammatory, creating a
diet that is anti-inflammatory.

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That is going to be some of the
best things we can do.

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And then we can also look at
other modalities like pulsed

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electromagnetic frequency,
acupressure, acupuncture, There

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00:19:47,280 --> 00:19:49,800
are lots of other modalities
that we can look at that are

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very beneficial for pain.
So with that, now if you do have

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any questions, please feel free
to reach out to me.

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And Instagram is usually the
best place to do that.

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00:19:58,680 --> 00:20:03,000
And I sincerely want to give
like my deepest sympathy to

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00:20:03,080 --> 00:20:06,880
anyone who trusted their
veterinarian to give this

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00:20:06,880 --> 00:20:10,400
pharmaceutical to their pet and
their pet has suffered because

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00:20:10,400 --> 00:20:11,520
of it.
It breaks my heart.

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So with that, I will talk to you
guys next week.

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I have a guest next week.
It's a very, very fun and

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00:20:17,840 --> 00:20:21,160
exciting episode.
I I please please, please don't

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00:20:21,160 --> 00:20:22,720
miss it.
You're going to want to catch it

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00:20:22,800 --> 00:20:27,360
right away as soon as it airs.
It is very time, like very much

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00:20:27,360 --> 00:20:30,160
the day it airs.
It is about that day.

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00:20:30,480 --> 00:20:34,280
So please set your reminders for
January 7th.

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00:20:34,280 --> 00:20:38,680
And that episode is with Amanda
Wilborn of The Nautical Dog, and

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00:20:38,680 --> 00:20:40,840
I cannot wait for you to hear
it.

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00:20:41,080 --> 00:20:44,640
So with that, I hope you and
your fur babies had a wonderful

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holiday and I will talk to you
next.